Margaret Cowie
- Born: 19 Nov 1805, Bothwell, Lanark, Scotland
- Christened: 24 Nov 1805, Bothwell, Lanark, Scotland
- Marriage (1): James Frame on 26 Jun 1830 in Lesmahagow, Lanark, Scotland
- Died: 5 Jun 1879, Lesmahagow, Lanark, Scotland at age 73
 Cause of her death was Chronic Bronchitis, 2.5 years/Anasarca, 3 months.
Margaret married James Frame, son of William Frame and Jean Unknown, on 26 Jun 1830 in Lesmahagow, Lanark, Scotland. (James Frame was born on 18 Jun 1806 in Avondale, Lanark, Scotland and died on 13 Jul 1893 in Bankend, Lesmahagow, Lanark, Scotland.). The cause of his death was Asthenia, 8 days.
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